Non-invasive method for monitoring cardiopulmonary parameters

ABSTRACT

A method for monitoring cardiopulmonary events is disclosed. The basic method comprises looping an extensible conductor (14) in close encircling relation about the neck (12) of the subject (10), providing a signal indicative of the inductance of the loop, and monitoring the signal. This signal contains both qualitative and quantitative cardiopulmonary information. In accordance with another aspect of the method, an extensible conductive loop (14) is disposed in close encircling relation about the head such that the plane defined by the loop extends through the mouth. By providing a signal indicative of changes in the inductance of the loop, qualitative and quantitative information for mouth volume may be obtained.

TECHNICAL FIELD

This invention pertains to non-invasive monitors of cardiopulmonaryparameters.

BACKGROUND ART

Apparatus and methods for monitoring cardiopulmonary parameters are, ofcourse, well known, and some such apparatus and methods arenon-invasive. Cardiopulmonary monitoring is clinically useful, forexample, in intensive care units and other applications. Despite theexistence of cardiopulmonary monitors in the prior art, it would behighly desirable to provide a simplified cardiopulmonary monitor whichdoes not substantially restrict patient movement, thereby rendering themonitor more suitable for long term use. Also, applicant is not aware ofany prior art monitoring techniques which employ a single transducerelement to monitor both cardiac and pulmonary parameters.

BRIEF DESCRIPTION OF THE DRAWINGS

In the drawings:

FIG. 1 is a perspective view showing a portion of the system formonitoring cardiopulmonary parameters in accordance with the method ofthe present invention;

FIG. 2A is a block diagram showing the full system for monitoringcardiopulmonary parameters in accordance with the method of the presentinvention;

FIG. 2B is partially schematic, partially diagrammatic representation ofa portion of the system illustrated in FIG. 2A;

FIGS. 3A-3J are tracings obtainable on a strip chart recorder when themethod of the present invention is practiced;

FIG. 4 is a view similar to FIG. 1 showing how to employ the method ofthe present invention for measuring arterial pulse wave velocity; and

FIG. 5 is a view similar to FIG. 1 showing another aspect of the methodin accordance with the present invention.

DISCLOSURE OF THE INVENTION

According to the present invention, I have found that variouscardiopulmonary events may be monitored by monitoring changes in thecross-sectional area of the neck, or by monitoring a parameterindicative of changes in cross-sectional area. In accordance with thepreferred basic method of the present invention, an extensible conductoris looped in close encircling relation about the neck, and suitablecircuitry is provided for measuring changes in the inductance of theloop, the changes in inductance being proportional to the changes incross-sectional area of the neck. The resulting signal, which may berecorded on a strip chart recorder or CRT, contains both cardiac andpulmonary information.

More specifically, the cardiac portion of the signal comprises thecarotid pulse, which may be isolated by time series averaging orappropriate filtering. Likewise, the pulmonary portion of the signal mayalso be isolated by time series averaging or appropriate filtering. Thepulmonary signal may be analyzed for time related respirationparameters, such as respiration rate, and inspiration and expirationtimes. The pulmonary signal may also be analyzed for specific pulmonaryevents, such as snoring, coughing, apneas, swallows, etc. These eventsproduce characteristic deflections or patterns which may beautomatically monitored by suitable circuitry for effecting leveldetection, rate detection or pattern recognition. I have also found thatthe pulmonary component of the signal may be calibrated to provide asignal semiquantitatively related to intrapleural pressure. For example,an esophageal balloon catheter may be employed to effect calibration.

In accordance with another aspect of the method in accordance with thepresent invention, I have found that changes in mouth volume as well asabsolute mouth volume may be detected by looping an extensibleconductive element about the head such that the plane defined by theloop extends through the mouth. If this is done, a signal indicative ofchanges in the inductance of the loop provides qualitative informationas to mouth volume. This information may be quantified, both for changesin the mouth volume and for absolute mouth volume, by calibrating thesignal. This aspect of the invention is particularly useful forobtaining information regarding puff volume and the proportion of smokeinhaled relative to total respiration volume.

The above as well as further aspects of the methods in accordance withthe present invention will become more fully apparent from the followingdetailed description and annexed drawings of the presently preferredbest modes thereof.

BEST MODE FOR CARRYING OUT THE INVENTION

In accordance with one aspect of the method in accordance with thepresent invention, an extensible electrically conductive loop isdisposed and held in close encircling relation about the neck. The endsof the loop are connected to circuits capable of providing a signalindicative of the changes in the self-inductance of the loop, which isin turn proportional to the changes in cross-sectional area enclosed bythe loop. By suitably processing the signal, a number of cardiopulmonaryparameters may be obtained.

Referring now to FIG. 1, the extensible electrically conductive loop 14disposed in close encircling relation about the neck 12 of the subject10 is preferably supported in any suitable fashion on an elastic tube 16or the like. The tube 16 preferably has two free ends (not shown) whichmay be releasably connected, as by Velcro strips, to facilitateplacement about the neck 12. The conductive loop 14 is renderedextensible by, for example, forming the loop in alternating up and downlooplets advancing in a plane. Numerous other configurations forrendering a conductive loop extensible, and for securing the conductiveloop to a tubular stretch bandage or the like, are disclosed in commonlyassigned application Ser. No. 102,408, entitled Method and Apparatus forMonitoring Respiration, filed Dec. 11, 1979, now U.S. Pat. No. 4,308,872the contents of which are hereby incorporated herein by reference intheir entirety. Changes in the cross sectional area of the neck portionenclosed by the conductive loop 14 cause the elastic tube 16 andconductive loop 14 to expand and contract, which results incorresponding changes in the cross sectional area and hence in theinductance of the loop. As explained below, if the inductance of theloop 14 is converted to an electrical signal, a number ofcardiopulmonary parameters for the subject 10 may be obtained.

Referring now to FIG. 2A, the preferred circuitry for converting theinductance of the loop 14 to a suitable electrical signal isdiagrammatically illustrated. As shown, a variable frequency oscillator18 is connected to the ends of the conductive loop 14. The resonantfrequency of the oscillator is determined by an internal capacitor andthe inductance of the conductive loop 14. This frequency may, forexample, be centered about 300 KHz and will vary as the loop 14 expandsand contracts. The output of the oscillator is connected to aconventional divide by sixteen counter 20 which reduces the frequency ofthe signal from the oscillator to minimize interference duringsubsequent signal transmission. As shown, the output of the counter 20is preferably coupled to a resistor 22 which converts the voltage signalat the output of the counter 20 to a corresponding current signal, thepurpose again being to minimize interference during signal transmission.To minimize artifacts, the electronics for the oscillator 18 and counter20 as well as the coupling resistor 22 are preferably incorporated in amodule 24 secured in any suitable fashion to the tubular bandage 16 onthe neck 12 of the subject 10 (FIG. 1).

The current signal at the output of the coupling resistor 22 isconnected via a suitable cable 26 to signal processing circuitryidentified in FIG. 2A by the box 28. The box 28 incorporates a digitalperiod (1/f) to voltage converter which provides a voltage signal whoseamplitude varies in response to the period of the signal at the outputof the counter 20. As will be more fully explained below, the circuitrepresented by the box 28 preferably also incorporates a microprocessorfor processing the voltage signal to yield certain types of usableinformation. The thus processed signal may then be displayed on one ormore suitable output devices, shown by way of example in FIG. 2A as aCRT terminal 30 and a strip chart recorder 32.

Suitable circuits for the oscillator 18 and counter 20 are available inthe prior art. For example, a suitable circuit for the oscillator 18 isdisclosed in above-mentioned U.S. Pat. No. 4,308,872. The counter 20 maycomprise the National Semiconductor CD4020. While prior art circuits arealso available for accomplishing the functions attributed to the box 28,a particular digital circuit has been developed for use with thisinvention which enhances the quality of the output signal. A schematicfor the preferred digital circuit represented by the box 28 in FIG. 2Ais shown in FIG. 2B. The construction and operation of the circuit ofFIG. 2B will be readily apparent to those skilled in the art.

Referring now to FIG. 3, tracings obtainable on the strip chart recorder32 in accordance with the method of the present invention are shown.Referring first to FIG. 3A, an AC coupled amplified unfiltered signalfrom the output of the box 28 in FIG. 2A is illustrated. In FIG. 3A,each large, irregularly shaped deflection 34 comprises one breath of thesubject 10, whereas the smaller deflections 36, which are most visibleon the descending portion of the deflections 34, comprise the carotidarterial pulse. As the signal at the output of the box 28 is a real timesignal, it will be immediately apparent that even the unfiltered signalillustrated in FIG. 3A contains clinically useable cardiopulmonaryinformation. For example, both the pulse rate and breath rate for thesubject 10 are readily visually observable in FIG. 3A. As explainedbelow, for particular applications the quality of the signal may beimproved by appropriate filtering. In FIG. 3A, base line drift resultsbecause the circuit of FIG. 2B is used in its AC coupled mode. However,and as will be apparent from the circuit of FIG. 2B, DC coupling is alsopossible.

As noted, the smaller deflections in FIG. 3A represent the carotidpulse, and it is apparent from FIG. 3A that the carotid pulse frequencyexceeds respiration frequency. Accordingly, the respiration signal maybe "cleaned up" by low pass filtering or, alternatively, time seriesaveraging may be used, as will be explained below. Low pass filtering ispreferably accomplished by the microprocessor incorporated in thecircuit of FIG. 2. Suitable programming for the microprocessor toaccomplish filtering is well within the capabilities of the skilled artworker. Referring to FIG. 3B, the signal at the output of the box 28 inFIG. 2A after suitable low pass filtering to remove the carotid pulse isshown. In FIG. 3B, each deflection 38 comprises one breath of thesubject 10. The gain setting on the strip chart recorder for FIGS. 3Aand 3B was the same. Again, base line drift is due to the fact that thedevice is AC coupled. It will be apparent that the tracing of FIG. 3Bmay be analyzed to yield the usual time related respiration parameters,e.g. respiration rate, inspiration time and expiration time.

Referring now to FIG. 3C, which was recorded with the same gain settingas for FIGS. 3A and 3B, and which was also filtered to remove thecarotid pulse component, a trace corresponding to artificially inducedapnea is shown. It is readily apparent from FIG. 3C that during apnea,the amplitude of the respiration signal 40 is vastly reduced as comparedwith the normal respiration signal of FIG. 3B. It will therefore beapparent that the cardiopulmonary monitoring method in accordance withthe present invention may be used to detect apneas by low pass filteringthe output signal, and then processing that signal through leveldetection circuitry to provide a suitable warning signal, e.g., aural orvisual, when the amplitude of the respiration signal decreases below apredetermined level for a predetermined time period. Suitable leveldetection circuitry for this application will be well within thecapabilities of the skilled art worker once this description is known.

Referring to FIG. 3D, coughs produce a signal characterized by largerapid upward deflections 42. In FIG. 3D, as well as FIGS. 3E-3G, thegain setting on the strip chart recorder was the same as that used forFIGS. 3A-3C. Also, in FIG. 3D, as well as FIGS. 3E-3G, the signals havebeen filtered to remove the carotid pulse component.

FIG. 3E shows a tracing taken with the subject 10 snoring, which alsoproduces a signal characterized by large upward deflections 44 if thecoil is placed at the upper portion of the neck above the larynx. Adownward deflection is produced if the coil is placed about the lowerportion of the neck below the larynx. FIG. 3F shows the characteristicsignal 46 resulting from jerking movements of the neck 12 of the subject10. FIG. 3G is a tracing taken with the subject's airway obstructed. Thecharacteristic rapid deflections 48 in FIG. 3G show the subject 10gasping for air.

FIG. 3H shows a signal 50 which results from talking. The strip chartrecorder 32 was set for a reduced gain for the tracing of FIG. 3H ascompared with the gain settings used for the tracings of FIGS. 3A-3G.

The tracing shown in FIG. 3I, which was taken with the same gain settingused for FIG. 3H, shows the signal 52 obtained when the subject 10swallows. Note that a swallow results in a characteristic negativedeflection 54.

It will thus be apparent that in addition to time related respiratoryparameters, the method of the invention yields a wide variety ofqualitative information. Thus, apneas, obstructions, coughs, snoring,and swallows may all be monitored, and specific events may be detectedby employing means, such as appropriate circuitry, for effecting leveldetection, rate detection and/or pattern recognition.

Where time related respiration parameters are to be monitored overextended periods, it is presently preferred to employ time seriesaveraging to eliminate the effect of artifacts resulting, for example,from neck movement. Basically, information from a plurality of breathsare averaged over a predetermined time interval, for example, oneminute, and then the respiration parameters are derived from theaverage. Since clinically significant changes in time related breathparameters do not generally occur in less than one minute, theprobability of losing significant data is minimal. In any event, ifdesired, both the averaged signal and the continuous signal may besimultneously monitored. Preferably, the microprocessor incorporated inthe circuit of FIG. 2 is programmed for time series averaging. As suchprogramming will be well within the capabilities of the skilled artworker once this description is known, a further description thereof isunncessary. It is also possible to obtain respiration parameters by timeseries averaging the unfiltered signal shown in FIG. 3A. If this isdone, an appropriate trigger signal could be obtained by differentiatingthe respiration signal available at the output of the system disclosedin U.S. Pat. No. 4,308,872.

Referring again to FIGS. 1 and 2, the system may be calibrated to yielda signal semi-quantitatively related to intrapleural pressure.Preliminary experiments indicate that calibrations for quiet and deepbreathing may differ from rapid expiratory events such as coughing. Itis proposed to employ an esophageal balloon catheter during thecalibration process. To effect calibration, the subject first swallowsthe esophageal balloon catheter, and then takes quiet and deep breathsand coughs with different efforts. During breathing and coughing,signals are simultaneously recorded for the neck coil 14 and thepressure at the esophageal balloon, the latter corresponding tointrapleural pressure. Based on these readings, the circuitry of FIG. 2is calibrated to provide an output signal which is semi-quantitativelyrelated to intrapleural pressure during these two events, i.e. breathingand coughing. Once calibration is complete, the esophageal ballooncatheter is removed, whereupon intrapleural pressure may be detectedfrom the neck coil signal alone.

Alternatively, it may be possible to obtain calibration values by havingthe subject make graded inspiratory efforts or graded expiratory effortsagainst a closed airway. Under these circumstances, i.e. closed airway,mouth pressure equals alveolar pressure which closely approximatesintrapleural pressure. Thus, breathing can be calibrated frominspiratory efforts and coughing from expiratory efforts utilizing mouthpressure. Finally, changes in intrapleural pressure may be assumed as apercent change from base line if it can be demonstrated that there is alinear or predictable relation between intrapleural pressure andbreathing or coughing thus obviating the need for placement of theesophogeal balloon catheter.

Referring again to FIG. 3A, when the signal component comprising thecarotid pulse is of interest, the respiration portion of the signal maybe removed by high pass filtering. Again, such high pass filtering ispreferably carried out by the microprocessor incorporated in the circuitof FIG. 2, and as suitable programming will be will within thecapabilities of the skilled art worker once this description is known, afurther description thereof is unnecessary. A high pass filtered signal54 showing only the carotid pulse is illustrated in FIG. 3J, whereineach deflection 56 comprises one pulse beat. It will immediately beapparent that pulse rate of the subject 10 is readily determinable fromFIG. 3J. Where pulse rate is to be monitored on a long term basis, thetime series averaging technique discussed above may be used to eliminate"noise" resulting, for example, from jugular vein or movement artifacts.Time series averaging would also be effective to obtain the pulse ratefrom the unfiltered signal shown in FIG. 3A. This is possible becausethe breath deflections 34 and carotid pulse deflections 36 are not timerelated. Consequently, if data storage is triggered from, for example,the R-wave portion of the electrocardiogram, the breath deflections willcancel out over time.

The carotid pulse signal obtained in accordance with the method of thepresent invention may be used with a phonocardiogram and an EKG, toobtain systolic time intervals in accordance with well known techniques.The nature of the transducer employed in connection with the method ofthe present invention for obtaining the carotid pulse, as compared withprior art transducers, enhances the results, especially with subjectmovement, such as occurs during exercise.

Referring now to FIG. 4, arterial pulse wave velocity may be detected bycomparing the carotid pulse signal with, for example, a brachial pulsesignal. As shown, the brachial pulse is preferably obtained by employinga transducer substantially identical to the one disposed about the neck,save for the fact that it is slightly smaller. Arterial pulse wavevelocity may be obtained by detecting the time differences between thecarotid and brachial pulse signals, the brachial pulse signal preferablybeing obtained by employing the circuitry of FIG. 2. For example, thetime differential between the upstroke of the carotid and brachialpulses may be used. Of course, pulse sites other than the brachialartery may be employed for this purpose. For example, the radial pulseor a finger pulse may be used.

It will now be apparent that both cardiac and pulmonary parameters canbe simultaneously monitored by splitting the output signal from the coil14 into two separate signals, and then processing one signal to yieldpulmonary parameters, and the other to yield cardiac parameters, all asis more fully explained above. Alternatively, two separate coils 14could be disposesd about the neck with the signal from each coil beingseparately processed. The two coil technique could also be employed forintrapleural measurements, where it is expected that calibration will bedifferent for breathing and rapid expiratory events.

Referring now to FIG. 5, in accordance with another aspect of the methodin accordance with the present invention, changes in the mouth volume ofthe subject 10 may be monitored. As shown in FIG. 5, this isaccomplished by disposing the extensible electrically conductive loop 14vertically about the head such that the plane defined by the coil passesthrough the subject's mouth. As shown in FIG. 5, this is preferablyaccomplished by disposing the coil 14 around the front part of thesubject's head and under the chin. Preferably, the coil 14, tube 16 andmodule 24 are of the same construction as that illustrated and describedabove in connection with FIG. 1. Likewise, the circuitry used forprocessing the inductance signal from the conductive loop 14 ispreferably identical with that illustrated in FIG. 2. If desired, anelastic band (not shown) may be disposed about the head in the vicinityof the forehead for holding the loop 14 and tube 16 in place.

Changes in mouth volume due to particular events, such as tonguemovement, results in characteristic signals which may be recorded on thestrip chart recorder 32. Monitoring changes in mouth volume inaccordance with the method of the present invention may be clinicallyuseful for detecting lack of rhythmic movements of the tonguesynchronous with inspiration as occurs in the obstructive sleep apneasyndrome.

The device illustrated in FIG. 5 may be calibrated to measure absolutevolumes or differential volumes. To calibrate for absolute volumes, thecoil 14 is preferably first placed about two forms having differentknown volumes, whereupon the circuitry of FIG. 2 may be calibrated basedon the resulting readings. For differential volume calibration, thedevice may be calibrated directly on the subject based on knownquantities of mouth volume. For example, the subject can be instructedto suck in air from a sensitive spirometer with graded efforts as inpuffing on a cigarette. When calibrated, the measurement obtainable withthe head coil over 10-100 ML volumes is ±10% of the measurement takenwith a sensitive spirometer. Still referring to FIG. 5, it is possibleto measure the volume of smoke puffed during smoking. To do so, it isonly necessary to measure the difference between the volume in the mouthbefore and after e.g. a cigarette puff. This information can also beused to determine the amount of smoke inhaled into the lungs relative tototal tidal volume. Thus, when a person first puffs on a cigarette, onlysmoke is initially drawn into the mouth. Accordingly, the cigarette puffis characterized by a generally increasing output signal from the facecoil, which eventually levels off at the end of the puff. The mouthvolume at the end of the puff is recorded. Once the puff is complete,the subject typically then inhales the smoke in the mouth, together withthe additional air into the lungs. The total tidal volume (smoke andair) may be measured in accordance with any one of a variety of knowntechniques, but preferably the technique disclosed in theabove-mentioned U.S. Pat. No. 4,308,872. Since the volume of inhaledsmoke has already been recorded, the proportion of smoke inhaledrelative to total respiration volume may be determined by dividing thevolume of smoke inhaled by total respiration volume. Also, the time ofbreath holding obtained from the system disclosed in U.S. Pat. No.4,308,872 provides an index of the amount of smoke that might bedeposited within the lungs. Finally, this method provides data on puffvolume and flow profile which should be helpful in establishingstandards for smoking machines used to assess the quantity of tar andnicotine in cigarettes.

Once the foregoing is known, it will be apparent that the presentlypreferred best modes for practicing the methods in accordance with thepresent invention may be modified in several respects. For example,while the above method has been described in connection with humansubjects, those skilled in the art will appreciate that it may beemployed with certain animal subjects as well. Also, while it ispresently preferred to measure changes in the cross-sectional area ofthe neck and head by measuring the changes in the inductance of aconductive loop, this is not essential. Thus, because changes in thecross-sectional area in the neck and head are relatively small, changesin circumference could be measured in lieu of changes in cross-sectionalarea, as the two are substantially proportional for small changes.Similarly, changes in volume, which will be proportional to changes incross-sectional area, could also be measured. Accordingly, in thefollowing claims, the phrase "detecting changes in cross-sectional areaor a parameter indicative thereof" should be understood to includecross-sectional area per se, as well as circumference and volume, bothof which are proportional to cross-sectional area as exlained above.

Since these as well as further changes and modifications are intended tobe within the scope of the present invention, the above descriptionshould be construed as illustrative and not in the limiting sense, thescope of the invention being defined by the following claims.

I claim:
 1. A method for non-invasively monitoring one or morecardiopulmonary events in a subject comprising:disposing about the neckmeans for detecting changes in cross-sectional area or a parameterindicative thereof; providing a signal indicative of the changes incross-sectional area or a parameter indicative thereof as detected bysaid detecting means; and monitoring said signal, said signal beingindicative of said cardiopulmonary events.
 2. The method according toclaim 1, wherein said disposing step comprises looping an extensibleconductor in close encircling relation about the neck and wherein saidsignal providing step comprises measuring changes in the inductance ofthe conductive loop.
 3. The method according to claim 2, wherein saidmonitoring step comprises processing said signal whereby to remove thecarotid arterial pulse component, and monitoring said processed signal.4. The method according to claim 3, wherein said processing stepcomprises low pass filtering said signal.
 5. The method according toclaim 4, further comprising time series averaging said signal.
 6. Themethod according to claim 3, wherein said processing step comprises timeseries averaging said signal.
 7. The method according to claim 3,further comprising calibrating said signal to provide a signalsemi-quantitatively related to intrapleural pressure.
 8. The methodaccording to claim 7, further comprising looping an additionalextensible conductor in close encircling relation about the neck,providing an additional signal indicative of the changes in theinductance of the additional conductive loop, processing the additionalsignal whereby to remove the carotid arterial pulse component, andcalibrating said first mentioned signal and said additional signal forrespiratory events having first and second frequencies, respectively. 9.The method according to claim 3, wherein said monitoring step comprisesmonitoring the amplitude of said signal to detect specific pulmonaryevents.
 10. The method according to claim 3, wherein said monitoringstep comprises monitoring the frequency of said signal to detectspecific pulmonary events.
 11. The method according to claim 3, whereinsaid monitoring step comprises monitoring the pattern of said signal todetect specific cardiopulmonary events.
 12. The method according toclaim 2, wherein said monitoring step comprises processing said signalwhereby to remove the respiration component, and monitoring saidprocessed signal.
 13. The method according to claim 12, wherein saidprocessing step comprises high pass filtering said signal.
 14. Themethod according to claim 13, further comprising time series averagingsaid signal.
 15. The method according to claim 12, wherein saidprocessing step comprises time series averaging said signal.
 16. Themethod according to claim 4, further comprising comparing said processedsignal with signals from an EKG and phonocardiogram whereby to determinesystolic time intervals.
 17. The method according to claim 12, whereinsaid monitoring step comprises monitoring the amplitude of said signalto detect specific cardiac events.
 18. The method according to claim 12,wherein said monitoring step comprises monitoring the frequency of saidsignal to detect specific cardiac events.
 19. The method according toclaim 12, wherein said monitoring step comprises monitoring the patternof said signal to detect specific cardiac events.
 20. The methodaccording to claim 2, wherein said monitoring step comprises splittingsaid signal into first and second signals, processing said first signalwhereby to remove the carotid arterial pulse component, processing saidsecond signal whereby to remove the respiration component, andmonitoring said processed first and second signals.
 21. The methodaccording to claim 2, further comprising looping an additionalextensible conductor in close encircling relation about another portionof the body of said subject at the site of a pulse other than thecarotid pulse;providing an additional signal indicative of the changesin the inductance of the additional conductive loop; and comparing thesignal from the conductor looped about the neck with said additionalsignal whereby to determine arterial pulse wave velocity.
 22. The methodaccording to claim 21, wherein said other pulse is the brachial, radialor finger pulse.
 23. The method according to claim 2, wherein saidmonitoring step comprises monitoring the amplitude of said signal todetect specific cardiopulmonary events.
 24. The method according toclaim 2, wherein said monitoring step comprises monitoring the frequencyof said signal to detect specific cardiopulmonary events.
 25. The methodaccording to claim 2, wherein said monitoring step comrpises monitoringthe pattern of said signal to detect specific cardiopulmonary events.26. The method according to claim 2, further comprising looping anadditional extensible conductor in close encircling relation about theneck; providing an additional signal indicative of the changes in theinductance of the additional conductive loop; and wherein saidmonitoring step comprises processing said first-mentioned signal andsaid additional signal to remove, respectively, the carotid arterialpulse component and the respiration component, and monitoring saidprocessed signals.